Stoned B mediates sorting of integral synaptic vesicle proteins
نویسندگان
چکیده
منابع مشابه
Interaction of stoned and synaptotagmin in synaptic vesicle endocytosis.
The Drosophila dicistronic stoned locus encodes two distinctive presynaptic proteins, Stoned A (STNA) and Stoned B (STNB); STNA is a novel protein without homology to known synaptic proteins, and STNB contains a domain with homology to the endocytotic protein AP50. Both Stoned proteins colocalize precisely with endocytotic proteins including the AP2 complex and Dynamin in the "lattice network" ...
متن کاملDrosophila stoned proteins regulate the rate and fidelity of synaptic vesicle internalization.
At an initial step during synaptic vesicle recycling, dynamin and adaptor proteins mediate the endocytosis of synaptic vesicle components from the plasma membrane. StonedA and stonedB, novel synaptic proteins encoded by a single Drosophila gene, have predicted structural similarities to adaptors and other proteins implicated in endocytosis. Here, we test possible roles of the stoned proteins in...
متن کاملThe stoned proteins regulate synaptic vesicle recycling in the presynaptic terminal.
The Drosophila stoned locus was identified 25 years ago on the basis of stress-sensitive behavioral mutants (Grigliatti et al., 1973). The locus is dicistronic and encodes two distinct proteins, stoned A and stoned B, which are expressed specifically in presynaptic terminals at central and peripheral synapses. Several stoned mutant alleles cause embryonic lethality, suggesting that these protei...
متن کاملLoss of Skywalker Reveals Synaptic Endosomes as Sorting Stations for Synaptic Vesicle Proteins
Exchange of proteins at sorting endosomes is not only critical to numerous signaling pathways but also to receptor-mediated signaling and to pathogen entry into cells; however, how this process is regulated in synaptic vesicle cycling remains unexplored. In this work, we present evidence that loss of function of a single neuronally expressed GTPase activating protein (GAP), Skywalker (Sky) faci...
متن کاملSynaptic vesicle proteins
What are they called? The uptake and storage of neurotransmitters is taken care of by the imaginatively named ‘neurotransmitter transporter proteins’ (as well as by ion channels and a proton ATPase). The synaptic vesicle proteins in the membrane trafficking class have mostly been given the prefix ‘synapto’, from the Latin meaning ‘to attach together’, and a suffix supposed to reflect a particul...
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ژورنال
عنوان ژورنال: Neuroscience
سال: 2008
ISSN: 0306-4522
DOI: 10.1016/j.neuroscience.2008.02.060